Anesthesia drugs used for cutting pain during surgery may increase the pain and discomfort after surgery.
The conclusion from a team of researchers from Georgetown University Medical Center, and offers a mechanism of how anesthetics can cause pain after surgery.
The researchers suggest that "noxious" anesthesia drugs - which are the basic and most frequently used drugs in the market - information specific neurons in the central nervous system, and this leads to pain after surgery. However, another group of drugs anesthesia - sevoflurane - targeting the brain and spinal cord, have no side effects, but they are not as effective.
Scientists have found that side effects of "bad" drugs due to the way drugs affect the nerve cells receptor TRPA1. This receptor is strongly activated by contact with "bad" drugs, which leads to burning pain after surgery.
They tested the "bad" drugs in mice lacking TRPA1 receptors and found that mice anesthetic agents did not feel any pain. The researchers then tested how harmful drugs and sevoflurane in normal mice and found that those exposed to harmful drugs experienced pain and inflammation several hours after exposure to anesthetic.
Finding suggests that the move to a group of anesthetic drugs with no side effects, or to develop more sophisticated methods.
"The choice of anesthesia may be a contributing factor of postoperative pain and inflammation," said Gerard Ahern, who led the study.
The conclusion from a team of researchers from Georgetown University Medical Center, and offers a mechanism of how anesthetics can cause pain after surgery.
The researchers suggest that "noxious" anesthesia drugs - which are the basic and most frequently used drugs in the market - information specific neurons in the central nervous system, and this leads to pain after surgery. However, another group of drugs anesthesia - sevoflurane - targeting the brain and spinal cord, have no side effects, but they are not as effective.
Scientists have found that side effects of "bad" drugs due to the way drugs affect the nerve cells receptor TRPA1. This receptor is strongly activated by contact with "bad" drugs, which leads to burning pain after surgery.
They tested the "bad" drugs in mice lacking TRPA1 receptors and found that mice anesthetic agents did not feel any pain. The researchers then tested how harmful drugs and sevoflurane in normal mice and found that those exposed to harmful drugs experienced pain and inflammation several hours after exposure to anesthetic.
Finding suggests that the move to a group of anesthetic drugs with no side effects, or to develop more sophisticated methods.
"The choice of anesthesia may be a contributing factor of postoperative pain and inflammation," said Gerard Ahern, who led the study.
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